Product name | Ademetionine 1,4-butanedisulfonate / SAM / SAMe |
CAS No. | 101020-79-5 |
Molecular Formula | C23H41N6O17S5- |
Molecular Weight | 833.91 |
Quality Standard | 99% up by HPLC |
Appearance | White powder |
COA of Ademetionine 1,4-butanedisulfonate |
ITEMS | STANDARDS | RESULTS |
Appearance | A white or almost white powder | White powder |
Solubility | Freely soluble in water, practically insoluble in ethanol and in acetone. | Conforms |
Identification | 1. The gas it produced can make wet potassium iodate test pater show blue. | Conforms |
2. UV: it has absorption maximum at the 258nm |
3. HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference. |
pH | 2.1~2.5 | 2.4 |
Clarity and color of solution | Color: ≤Y3# or YG3# | Conforms |
A solution should be clear. |
Isomers | (S,S-Isomer) ≥70% | 74.00% |
Related substances | Adenine≤0.4% | 0.05% |
S-Adenosyl-L-Homocysteine≤0.4% | 0.09% |
Methylthioadenosine≤2.0% | 0.43% |
Decarboxylation adenosine methionine≤1.2% | 1.00% |
The other unknown impurities≤1.0% | 0.05% |
Total of impurities≤4.0% | 1.80% |
Water | ≤6.0% | 2.40% |
Residual solvents | Ethyl acetate≤5000ppm | Conforms |
Microbial limit tests | Bacteria≤1000cfu/g | Conforms |
Bacterial endotoxins | ≤0.438 EU/mg | Conforms |
Content (dried basis) | Butanedisuphonic acid: 46.0~51.0% | 47.20% |
Adenosine methionine: 48.0~53.0% | 52.20% |
Total≥96.0% | 99.40% |
Conclusion | Conforms to enterprise standard |
Function of Ademetionine 1,4-butanedisulfonate
Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.
The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:
1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.
2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.
3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.
Indication of Ademetionine 1,4-butanedisulfonate:
Suitable for intrahepatic cholestasis before and after cirrhosis.
Suitable for intrahepatic cholestasis during pregnancy.
