Product name | Lacidipine |
CAS No. | 103890-78-4 |
Molecular Formula | C26H33NO6 |
Molecular Weight | 455.543 |
Quality Standard | 99% up, Medicine Grade |
Appearance | White powder |
TEST | STANDARD | RESULT |
Appearance: | white or almost white powder, slightly hygroscopic, ordorless | Confirms |
Very solutable in acetonitrile or chloroform, Soluble in Water, very soluble and practically insolutable in ethyl ether | Confirms |
Identification | (1) IR | Conforms |
(2) HPLC | Conforms |
Water | NMT 5.0% | 0.6% |
Residue on ignition | NMT 0.2% | 0.1% |
Methyl benzenesulfonate | NMT 0.1% | undetected |
Toluene | NMT 890ppm (ICH) | 102ppm |
Chromatographic purity | (1) Laudanosine: NMT 0.5% (2) Other individual impurities: NMT 1.0% (3) Total Impurities: NMT 3.5% | 0.01% 0.38% 1.3% |
Isomer Ratio | Trans-Trans Isomer: 5%-6.5% | 5.7% |
| Cis-Trans Isomer: 34.5%-38.5% | 36% |
| Cis-Cis Isomer: 55%-60% | 58.2% |
Assay | 96%-102% (C65H82N2O18S2 on anhydrous basis) | 100.2% |
Residue Solvents | (1) Dichloromethane: NMT 600ppm (2) Acctonitrile: NMT 410ppm (3) Ethyl ether: NMT 5000ppm | Undetected Undetected 1739ppm |
Result | Confirms to USP34 |
Function of Lacidipine
Lacidipine can be used to treat high blood pressure. This product is a specific, potent and long-lasting dihydropyridine calcium channel blocker, which mainly selectively blocks the calcium channel of vascular smooth muscle, dilates the surrounding arteries, reduces peripheral vascular resistance, reduces cardiac afterload, and lowers blood pressure.
