Abstract: Late treatment with alpha GPC for increasesing hippocampal neurogenesis and providing protection against epilepsy seizure-induced neuronal death and cognitive impairment

Choline alfoscerate (α-GPC; alpha GPC; L-alpha glycerylphosphorylcholine; CAS No.:28319-77-9) is common choline compound and acetycholine precursor in the brain, which has been shown to be effective in the treatment of Alzheimer’s disease and dementia. α-GPC has been shown to enhance memory and cognitive function in stroke and Alzheimer’s patients but currently remains untested in patients suffering from epilepsy. This study aimed to evaluate whether α-GPC treatment after seizure can ameliorate seizure -induced cognitive impairment and neuronal injury.

improvement of cognitive function in epilepsy patients.

Reference:

Late treatment with choline alfoscerate (L-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment

Song Hee Lee, Bo Young Choi, Jin Hee Kim, A.Ra Kho, Min Sohn, Hong Ki Song,Hui Chul Choi
, Sang Won Suha
Department of Physiology, Hallym University, College of Medicine, Chuncheon, Republic of Korea
Department of Neurology, Hallym University, College of Medicine, Chuncheon, Republic of Korea

Inha University, Department of Nursing, Incheon, Republic of Korea
Hallym Institute of Epilepsy Research, Hallym University, College of Medicine, Chuncheon, Republic of Korea

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