Product name | Semaglutide |
CAS No. | 910463-68-2 |
Sequence | H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys[(AEEA)2-γ-Glu-N-(17-carboxy-1-oxoheptadecyl)]-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
Molecular Formula | C187H291N45O59 |
Molecular Weight | 4113.57754 |
Quality Standard | 98% up by HPLC |
Appearance | White powder |
Function of Semaglutide
Semeglutide is a long-acting glucagon-like peptide 1 (GLP-1) analog, a GLP-1 receptor agonist, and has potential therapeutic efficacy in type II diabetes mellitus (T2DM).
Compared with liraglutide, semaglutide has a longer aliphatic chain and increased hydrophobicity, but semaglutide is modified with a short chain of PEG, and its hydrophilicity is greatly enhanced. After PEG modification, it can not only bind closely to albumin, cover the enzymatic hydrolysis site of DPP-4, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation.
