Saxagliptin Intermediate 361440-67-7

(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester  is one of key Intermediate of Saxagliptin.

Physical properties about (1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester are: 

(1)ACD/LogP: -0.534;

(2)ACD/LogD (pH 5.5): -0.53;

(3)ACD/LogD (pH 7.4): -0.53;

(4)ACD/BCF (pH 5.5): 1.00;

(5)ACD/BCF (pH 7.4): 1.00;

(6)ACD/KOC (pH 5.5): 12.20;

(7)ACD/KOC (pH 7.4): 12.20;

(8)#H bond acceptors: 5;

(9)#H bond donors: 2;

(10)#Freely Rotating Bonds: 3;

(11)Index of Refraction: 1.538;

(12)Molar Refractivity: 57.6 cm3;

(13)Molar Volume: 184.139 cm3;

(14)Polarizability: 22.834 10-24cm3;

(15)Surface Tension: 49.5180015563965 dyne/cm;

(16)Density: 1.229 g/cm3;

(17)Flash Point: 189.024 °C;

(18) Enthalpy of Vaporization: 63.821 kJ/mol;

(19)Boiling Point: 388.94 °C at 760 mmHg