Hydroxy-1-Adamantyl-D-Glycine / Saxagliptin Intermediate

Boc-3-Hydroxy-1-adamantyl-D-glycine is one of key Intermediate of Saxagliptin.

Physical properties about Boc-3-Hydroxy-1-adamantyl-D-glycine are:

(1)ACD/LogP: 1.97;

(2)# of Rule of 5 Violations: 0 ;

(3)#H bond acceptors: 6;

(4)#H bond donors: 3;

(5)#Freely Rotating Bonds: 6;

(6)Polar Surface Area: 95.86 Å2;

(7)Index of Refraction: 1.575;

(8)Molar Refractivity: 82.911 cm3;

(9)Molar Volume: 251.06 cm3;

(10)Polarizability: 32.868 ×10-24cm3;

(11)Surface Tension: 59.817 dyne/cm;

(12)Density: 1.296 g/cm3;

(13)Flash Point: 254.53 °C;

(14)Enthalpy of Vaporization: 88.13 kJ/mol;

(15)Boiling Point: 497.253 °C at 760 mmHg;

(16)Vapour Pressure: 0 mmHg at 25°C.

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