3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride 762240-92-6

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is one of key intermediates of Sitagliptin.

Physical properties of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride are:
(1)ACD/LogP:  -0.206;

(2)# of Rule of 5 Violations:  0;

(3)#H bond acceptors:  4;

(4)#H bond donors:  1;

(5)#Freely Rotating Bonds:  0;

(6)Flash Point:  114.8 °C;

(7)Enthalpy of Vaporization:  50.41 kJ/mol ;

(8)Boiling Point:  266.2 °C at 760 mmHg;

(9)Vapour Pressure:  0.00879 mmHg at 25°C.

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