Product name | Lubiprostone |
CAS No. | 333963-40-9 |
Molecular Formula | C20H32F2O5 |
Molecular Weight | 390.46 |
Molecular Structure |  |
Quality Standard | 99% up by HPLC, for R&D use only |
Appearance | White powder |
Items | Standards | Results |
Appearance | White crystals or crystalline powder, odorless | Complies |
Identification | By IR | Complies |
By HPLC | Complies |
Water Content | ≤ 0.50% | 0.22% |
Heavy Metals | ≤ 10ppm | Complies |
Residual Solvent | n-Hexane: ≤ 290ppm | ND |
Ethyl acetate: ≤ 5000ppm | 0.12% |
Related Substances | Total impurities: ≤1.00% | 0.04% |
Purity(HPLC) | ≥ 99.0% | 99.96% |
Reference Standard | In-house Standard |
Conclusion | The product complied to In-house standard. |
Function of Lubiprostone
Lubiprostone is a limited chloride channel activator, which can selectively activate the type 2 chloride channel (CIC-2) located on the luminal cell membrane of the epithelial tip of the gastrointestinal tract to increase the secretion of intestinal juice and intestinal motility, thereby Increase bowel movements, reduce the symptoms of chronic idiopathic constipation, and do not change the concentration of sodium and potassium in the plasma.
Application of Lubiprostone
Adult chronic idiopathic constipation, constipation-type irritable bowel syndrome (only for female patients over 18 years old);
