Product name | Mupirocin |
Molecular Formula | C26H44O9 |
Molecular Weight | 500.6222 |
CAS No. | 12650-69-0 |
Quality Standard | GMP / USP34 / EP6 |
Appearance | white powder |
ITEMS | SPECIFICATIONS | RESULT |
Appearance | A white or off-white powder | Conforms |
Identification(A,B) | Positive | Conforms |
Specific Optical Rotation | -20°~ -16° | -18° |
Impurity C | Not more than 2.5% | 1.6% |
Individual impurity | Not more than 1.0% | Conforms |
Total impurities | Not more than 4.5% | 3.5% |
Chlorides | Not more than 0.5% | Conforms |
PH | 3.0~4.5 | 3.6 |
Water | Not more than 1.0% | 0.1% |
Residual Solvents | Ethyl Acetate | Not more than 500 ppm | Not deteced |
Isobutyl Acetate | Not more than 5000 ppm | 5 |
Heptane | Not more than 500 ppm | 2 |
Acetone | Not more than 3000 ppm | 15 |
Assay | 93.0-102.0% | 98.1% |
Mupirocin is a topical antibiotic for external use, which is a substance produced by Pseudomonas fluorescens culture fluid, namely Pseudomonas A. Its antibacterial effect is mainly by reversibly combining with isoleucine transfer RNA synthetase, preventing isoleucine infiltration, and stopping the synthesis of isoleucine-containing protein in cells to play a bactericidal or bacteriostatic role. Mupirocin shows bacteriostatic effect at very low concentration and bactericidal effect at high concentration. Mupirocin is highly sensitive to various Gram-positive cocci related to skin infections, especially Staphylococcus and Streptococcus. It is also effective against resistant Staphylococcus aureus; Neisseria gonorrhoeae has some antibacterial effect; it is not sensitive to most anaerobic bacteria and normal skin flora. The incidence of drug-resistant mutants in vitro is very low.
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